連合創薬医療情報研究科 本田諒研究室
1.発表論文
2023年6月時点で英文原著論文27報(筆頭7報、責任11報)を発表しています。
※IF (impact factor)とCiteScoreは発表当時の値です。
1Kento Wakayam, Shintaro Kimura, Yui Kobatake, Hiroaki Kamishina, Naohito Nishii, Satoshi Takashima, Ryo Honda, and *Yuji O. Kamatari: Molecular Mechanisms of Aggregation of Canine SOD1 E40K Amyloidogenic Mutant Protein, Molecules 28, no. 1 (2022): 156. (IF 4.93, CiteScore 5.9)
Tatsushi Nakayama, Ryo Honda, Kazuo Kuwata, Shigeyuki Usui, Bunji Uno: Electrochemical and Mechanistic Study of Reactivities of α-, β-, γ-, and δ-Tocopherol toward Electrogenerated Superoxide in N, N-Dimethylformamide through Proton-Coupled Electron Transfer. Antioxidants. 11(1), 9, 2022 (IF 6.31, CiteScore 4.5)
*Kazuki Heishima, Nobuhiko Sugito, Tomoyoshi Soga, Masashi Nishikawa, Yuko Ito, Ryo Honda, Yuki Kuranaga, Hiroki Sakai, Ryo Ito, Takayuki Nakagawa, Hiroshi Ueda, and Yukihiro Akao: Petasin potently inhibits mitochondrial-complex-I-based metabolism supporting tumor growth and metastasis, Journal of Clinical Investigation 131(17), 2021 (IF 14.8, CiteScore 17.7)
*Tatsushi Nakayama and Ryo Honda: Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electro-generated Superoxide through Proton-coupled Electron Transfer, ACS Omega 6(33), 21730-21740, 2021 (IF 3.51, CiteScore 3.9)
Teiko K Nomura, Kazuki Heishima, Nobuhiko Sugito, Ryota Sugawara, Hiroshi Ueda, Akao Yukihiro, and *Ryo Honda: Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains, Cell Chemical Biology 28(18), 1581-1589, 2021 (IF 8.12, CiteScore 12.9)
Satoshi Yamashita, Yuji O. Kamatari, Ryo Honda, Ayumi Niwa, Hiroyuki Tomiata, Akira Hara, and *Kazuo Kuwata: Monomeric a-synuclein (aS) inhibits amyloidogenesis of human prion protein (hPrP) by forming a stable aS-hPrP hetero-dimer, Prion 15(1), 37-43, 2021. (IF 1.95, CiteScore 3.0)
*Tatsushi Nakayama and Ryo Honda: Electrochemical and Mechanistic Study of Superoxide Elimination by Mesalazine through Proton-Coupled Electron Transfer, Pharmaceuticals, 14(2), 120, 2021 (IF 4.29, CiteScore 5.4)
Shintaro Kimura, Yuji O. Kamatari, Yukina Kuwahara, Hideaki Hara, Osamu Yamato, Sadatoshi Maeda, Hiroaki Kamishina, and *Ryo Honda: Canine SOD1 harboring E40K or T18S mutations promotes protein aggregation without reducing the global structural stability, PeerJ, 8, e9512, 2020 (IF 2.35, CiteScore 3.5)
Satoshi Yamashita, Ryo Honda, Mayuko Fukuoka, Tsutomu Kimura, Junji Hosokawa-Muto, and Kazuo Kuwata: Discovery of a multipotent chaperone, 1-(2, 6-Difluorobenzylamino)-3-(1, 2, 3, 4-tetrahydrocarbazol-9-yl)-propan-2-ol with the inhibitory effects on the proliferation of prion, cancer as well as influenza virus, Prion, 14(1), 42-46, 2020 (IF 1.60, CiteScore 2.60)
Maki Shirasaka, Kazuo Kuwata, and *Ryo Honda: α-Synuclein chaperone suppresses nucleation and amyloidogenesis of prion protein, Biochemical and Biophysical Research Communications 521 (1), 259-264, 2020 (IF 2.71, CiteScore 2.69)
Takuya Tsujino, Nobuhiko Sugito, Kohei Taniguchi, Ryo Honda, Kazumasa Komura, Yuki Yoshikawa, Tomoaki Takai, Koichiro Minami, Yuki Kuranaga, Haruka Shinohara, Yoshihisa Tokumaru, Kazuki Heishima, Teruo Inamoto, Haruhito Azuma, and *Yukihiro Akao: MicroRNA‐143/Musashi‐2/KRAS cascade contributes positively to carcinogenesis in human bladder cancer, Cancer science 110 (7), 2189-2199, 2019 (IF 4.75, CiteScore 4.48)
Ryota Sugawara, Hiroshi Ueda, and *Ryo Honda: Structural and functional characterization of fast-cycling RhoF GTPase, Biochemical and biophysical research communications 513 (2), 522-527, 2019 (IF 2.56, CiteScore 2.62)
Kyosuke Kakuda, Ayumi Niwa, Ryo Honda, Kei-ichi Yamaguchi, Hiroyuki Tomita, Md Nojebuzzaman, Akira Hara, Yuji Goto, Masatake Osawa, Kazuo Kuwata.: A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia, The Journal of Biochemistry 165 (4), 369-378, 2019 (IF 2.35, CiteScore 2.31)
Kyosuke Kakuda, Kei-ichi Yamaguchi, Kazuo Kuwata, *Ryo Honda: A valine-to-lysine substitution at position 210 induces structural conversion of prion protein into a β-sheet rich oligomer, Biochemical and biophysical research communications 506 (1), 81-86, 2018 (IF 2.47, CiteScore 2.62)
*Ryo Honda, Kei-ichi Yamaguchi, Abdelazim Elsayed Elhelaly, Mitsuhiko Fuji, Kazuo Kuwata: Poly-L-histidine inhibits prion propagation in a prion-infected cell line, Prion 12 (3-4), 226-233, 2018 (IF 2.01, CiteScore 2.11)
*Ryo Honda and Kazuo Kuwata: Evidence for a central role of PrP Helix 2 in the nucleation of amyloid fibrils, The FASEB Journal 32 (7), 3641-3652, 2018 (IF 5.50, CiteScore 4.53)
*Ryo Honda: Amyloid-β peptide induces prion protein amyloid formation: Evidence for its widespread amyloidogenic effect, Angewandte Chemie - International Edition, 57 (21), 6086-6089, 2018 (IF 11.99, CiteScore 11.31)
Kei-ichi Yamaguchi, Ryo P Honda, Abdelazim Elsayed Elhelaly, *Kazuo Kuwata: Acceleration of nucleation of prion protein during continuous ultrasonication, The Journal of Biochemistry 163 (6), 503-513, 2018 (IF 2.35, CiteScore 2.31)
*Ryo Honda: Role of the disulfide bond in prion protein amyloid formation: a thermodynamic and kinetic analysis, Biophysical Journal 114 (4), 885-892, 2018 (IF 3.66)
Amin Tahoun, Hisayoshi Masutani, Hanem El-Sharkawy, Trudi Gillespie, Ryo P Honda, Kazuo Kuwata, Mizuho Inagaki, Tomio Yabe, Izumi Nomura, *Tohru Suzuki: Capsular polysaccharide inhibits adhesion of Bifidobacterium longum 105-A to enterocyte-like Caco-2 cells and phagocytosis by macrophages, Gut pathogens 9 (1), 27,1, 2017 (IF 2.76)
*Ryo P Honda, *Kazuo Kuwata: The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro, Scientific Reports 7 (1), 562, 2, 2017 (IF 5.23)
Satoshi Endo*, Sayaka Takada, Ryo P Honda, Kathrin Müller, Jochen H Weishaupt, Peter M Andersen, Albert C Ludolph, Yuji O Kamatari, Toshiyuki Matsunaga, Kazuo Kuwata, Ossama El-Kabbani, Akira Ikari: Instability of C154Y variant of aldo-keto reductase 1C3, Chemico-biological interactions, 276, 194-202, 2016 (IF 2.58)
Aurangazeb Kabir, Ryo P Honda, Yuji O Kamatari, Satoshi Endo, Mayuko Fukuoka, *Kazuo Kuwata: Effects of ligand binding on the stability of aldo–keto reductases: Implications for stabilizer or destabilizer chaperones, Protein Science 25 (12), 2132-2141, 2016 (IF 3.04)
Ryo P Honda, Ming Xu, Kei-ichi Yamaguchi, Heinrich Roder, *Kazuo Kuwata: A native-like intermediate serves as a branching point between the folding and aggregation pathways of the mouse prion protein, Structure 23 (9), 1735-1742, 11, 2015 (IF 5.23)
Ryo P Honda, Kei-ichi Yamaguchi, *Kazuo Kuwata: Acid-induced molten globule state of a prion protein crucial role of strand 1-helix 1-strand 2 segment, Journal of Biological Chemistry 289 (44), 30355-30363, 2014 (IF 4.26)
2.知的財産権
特願2020-137653、PCT/JP2021/028880、「人工タンパク質、Ras阻害剤及び抗がん剤」、発明者:本田諒、赤尾幸博
2023年7月出願予定、「異常型タンパク質の検出方法及び神経変性疾患の検査方法」、発明者:本田諒、下畑享良、位田雅俊
3.公的資金の獲得状況
令和4年度~令和6年度 AMED革新的がん医療実用化研究事業「Non-G12C変異型RASを標的とするキメラ型タンパク質の開発」研究代表者 総額3,003万円(直接経費2,310万円、間接経費693万円)
令和4年度~令和5年度 文部科学省(若手研究)「がん遺伝子産物RASを阻害する細胞膜透過性タンパク質の開発」研究代表者 総額468万円(直接経費360万円、間接経費108万円)
令和2年度 AMED橋渡し研究戦略的推進プログラム(シーズA)「Rasを標的とした細胞膜透過性タンパク質の開発」研究代表者 総額504.7万円
令和元年~令和3年度 文部科学省(若手研究)「変異型Rasに高親和性かつ特異的に結合するタンパク質を用いた新規抗がん剤の開発」研究代表者 総額416万円
平成 28~29 年度 文部科学省(特別研究員奨励費)「蛋白質異常凝集の初期段階の解明・制御」研究代表者 総額416万円